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- Title
Erythropoietin in Cerebrospinal Fluid: Age-related Reference Values and Relevance in Neurological Disease.
- Authors
Karin Widl; Johannes Brettschneider; Dagmar Schattauer; Sigurd Süßmuth; Roman Huber; Albert Ludolph; Hayrettin Tumani
- Abstract
Abstract We aimed to establish age-related reference values for Erythropoietin (EPO) in cerebrospinal fluid (CSF) and to evaluate concentrations in neurological diseases. CSF and serum EPO was measured in controls with tension-type headache (CTTH), in patients with ALS, dementia and depression using ELISA technique. Stability experiments showed CSF EPO to be stable for two and a half months and over two thaw/freeze cycles. A positive correlation of CSF EPO with age was found (P P The establishment of age-related reference values in a large cohort of controls will improve the interpretation of future CSF EPO evaluations in neurological diseases.
- Subjects
ERYTHROPOIETIN; CEREBROSPINAL fluid; NEURONS; ENZYME-linked immunosorbent assay; DISEASES
- Publication
Neurochemical Research, 2007, Vol 32, Issue 7, p1163
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-007-9286-0