We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Anti-Cancerous and Anti-Inflammatory Activities of some Novel Schiff Bases Derived from 2-[(1,3-benzothiazol-2-yl)sulfanyl]-N-[4-(hydrazinecarbonyl)phenyl]acetamide.
- Authors
Gulzar, Aqsa; Mahmud, Tariq; Munir, Rubina; Anjum, Asma
- Abstract
The anti-cancerous and anti-inflammatory potential of two novel Schiff bases was carried out by MTT - colorimetric protocol on HeLa cells (cervical disease) and Luminol-improved chemiluminescence assay, respectively. The novel Schiff bases 4a and 4b have been synthesized by the reaction of 2-[(1,3-benzothiazol-2-yl)sulfanyl]-N-[4-(hydrazinecarbonyl)phenyl]acetamide with 3-nitro and 4-nitrobenzaldehyde. Characterization of the synthesized compounds was done by using various spectroscopic techniques namely FTIR, proton and carbon-13 NMR, Mass spectrometry and elemental analysis. The results were in great consistency with the structures of the synthesized compounds and confirmed the formation of the targeted compounds. It was found that the compound 4a was potentially anti-inflammatory active while the compound 4b was found more active anti-cancerous agent as compared to 4a.
- Subjects
ANTINEOPLASTIC agents; SCHIFF bases; ACETAMIDE; CHEMILUMINESCENCE; FOURIER transform infrared spectroscopy
- Publication
Pakistan Journal of Zoology, 2018, Vol 50, Issue 3, p1003
- ISSN
0030-9923
- Publication type
Article
- DOI
10.17582/journal.pjz/2018.50.3.1003.1009