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- Title
MYEOV gene overexpression in primary plasma cell leukemia with t(11;14)(q13;q32).
- Authors
COCCARO, NICOLETTA; TOTA, GIUSEPPINA; ANELLI, LUISA; ZAGARIA, ANTONELLA; CASIERI, PAOLA; CELLAMARE, ANGELO; MINERVINI, CRESCENZIO FRANCESCO; MINERVINI, ANGELA; CUMBO, COSIMO; IMPERA, LUCIANA; BRUNETTI, CLAUDIA; ORSINI, PAOLA; PARCIANTE, ELISA; MESTICE, ANNA; SPECCHIA, GIORGINA; ALBANO, FRANCESCO
- Abstract
Primary plasma cell leukemia (pPCL) is an uncommon form of plasma cell dyscrasia, and the most aggressive of the human monoclonal gammopathies. The t(11;14)(q13;q32) rearrangement is the most common alteration in pPCL, promoting cyclin D1 (CCND1) gene overexpression caused by its juxtaposition with the immunoglobulin heavy locus chromosome region. The myeloma overexpressed (MYEOV) gene maps very close to the CCND1 gene on chromosome 11, but its overexpression is rarely observed in multiple myeloma. The present study describes a case of pPCL with t(11;14) characterized by a breakpoint on der(11), unlike the one usually observed. Droplet digital polymerase chain reaction analysis revealed overexpression of CCND1 and MYEOV. To the best of our knowledge, MYEOV gene overexpression has never been previously described in pPCL.
- Subjects
MYELOMA proteins; GENETIC overexpression; PLASMA cell leukemia; MANTLE cell lymphoma; CHROMOSOMAL translocation; PHYSIOLOGICAL control systems; CYCLINS; BRAF genes
- Publication
Oncology Letters, 2016, Vol 12, Issue 2, p1460
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.4759