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- Title
Influence of diameter of fiber membrane scaffolds on the biocompatibility of hPDL mesenchymal stromal cells.
- Authors
SUAREZ-FRANCO, José Luis; VÁZQUEZ-VÁZQUEZ, Febe Carolina; POZOS-GUILLEN, Amaury; MONTESINOS, Juan José; ALVAREZ-FREGOSO, Octavio; ALVAREZ-PEREZ, Marco Antonio
- Abstract
This study evaluated the influence in the biocompatibility of human periodontal ligament (hPDL) mesenchymal stromal cell onto poly lactic-acid (PLA) films and PLA fiber membrane. Fiber scaffold was prepared via air jet spinning (AJS) from PLA solutions (6, 7, and 10%) and analyzed using SEM, AFM and FTIR. Biocompatibility was evaluated by adhesion, proliferation and cell-material interaction. PLA film exhibited a smooth and homogenously surface topography in comparison with random orientation of PLA fiber with roughness structure where diameter size depends on PLA solution. Moreover, cell adhesion; proliferation and cell-material interaction has the best respond on random orientation nanofiber of 10, followed by 7, and 6% of PLA in comparison with PLA films. It could be concluded that AJS is an attractive alternative technique for manufacture fiber scaffolds with a tunable random orientation geometry of fibers that allow to produce interconnected porous formed by nanometric fiber diameter structures that could be a potential scaffold for periodontal tissue engineering applications.
- Subjects
MESENCHYMAL stem cells; STROMAL cells; PERIODONTAL ligament; CELL proliferation; CELL adhesion
- Publication
Dental Materials Journal, 2018, Vol 37, Issue 3, p465
- ISSN
0287-4547
- Publication type
Article
- DOI
10.4012/dmj.2016-329