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- Title
The Journey to Establish CGRP as a Migraine Target: A Retrospective View.
- Authors
Edvinsson, Lars
- Abstract
In this retrospective, Dr. Lars Edvinsson recounts early steps and milestones in our understanding of the neuropeptide calcitonin gene-related peptide (CGRP) in the trigeminovascular system and its role in migraine. The discovery of the presence and function of CGRP and other neuropeptides in the cerebral vasculature and its sensory innervation is described. He relates the seminal finding that CGRP is uniquely released during migraine and the journey to develop blockers of CGRP effects. Now, over 30 years since its discovery, CGRP has become the target for a number of promising novel treatments for migraine patients.
- Subjects
CEREBRAL artery physiology; AUTONOMIC nervous system; CELL receptors; CEREBRAL circulation; MIGRAINE; NERVE block; NEUROPEPTIDES; RESEARCH funding; TRIGEMINAL nerve
- Publication
Headache: The Journal of Head & Face Pain, 2015, Vol 55, Issue 9, p1249
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/head.12656