We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
HLA Control of the Proliferative T Lymphocyte Response to Antigenic Determinants on Mumps Virus.
- Authors
Bruserud, Ø.; Thorsby, E.
- Abstract
The proliferative T lymphocyte responses to two different mumps antigen preparations, S (nucleocapsid) and V (viral envelope), were characterized. Eight patients with Type I (insulin- dependent) diabetes mellitus were all found to be responders to S and V mumps antigen. Among the 64 healthy individuals, 52 were classified as responders to the S antigen and 5U as responders to the V antigen. No difference was found between T lymphocytes from Type 1 diabetic patients and those from healthy individuals as regards the effect of indomethacin on the mumps-specific response. The majority of the mumps specific T lymphocytes seemed to be restricted by epitopes on the HLA-DR molecules. The frequency of mumps antigen-reactive T lymphocytes (ARTL) was found to be low when the response was restricted by DR3-associated elements, and high when it was restricted by DR4-associated elements, compared to the frequency of ARTL when other DR-associated elements restricted the mumps-specific response. For the majority of the individuals tested. The DR-associated hypo- and hyper-responsiveness was found with both the S and the V mumps antigens.
- Subjects
HLA histocompatibility antigens; T cells; VIRUSES; EPITOPES; MUMPS; IMMUNOLOGY; DIABETES; LEUCOCYTES; LYMPHOCYTES; HYPOGLYCEMIC agents; PANCREATIC secretions; ENDOCRINE diseases; CARBOHYDRATE intolerance
- Publication
Scandinavian Journal of Immunology, 1985, Vol 22, Issue 5, p509
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1985.tb01910.x