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- Title
β<sub>2</sub>-Microglobulin is Bound to Streptococcal M Protein.
- Authors
Björck, L.; Tylewska, S. K.; Wadström, T.; Kronvall, G.
- Abstract
The presence of receptors for three human proteins (fibrinogen, IgG, and β2-microglobulin (β2m)) was studied in group A streptococcal strains. M type 1, 12 and 14, and in M protein- negative variants of these strains. Fibrinogen binding was detected in all six strains, IgG did not bind to the two type-12 strains and uptake was low in both type-14 strains. The type-1, M protein- positive strain was negative in binding experiments with radiolabelled IgG, whereas the M protein-negative variant was strongly positive. Aggregated β2m showed a high degree of re- activity with the M protein-positive strains but not with the corresponding M protein-negative variants. The results indicate that the receptor for aggregated β2m is located on M protein in group A streptococci.
- Subjects
IMMUNOGLOBULIN G; FIBRINOGEN; PROTEINS; STREPTOCOCCUS; MEDICAL microbiology; IMMUNOLOGY
- Publication
Scandinavian Journal of Immunology, 1981, Vol 13, Issue 4, p391
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1981.tb00149.x