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- Title
Unexpected consequences of proton pump inhibitor use
- Authors
Altman, Kenneth W.; Radosevich, James A.
- Abstract
Abstract: Proton pump inhibitors (PPIs) are among the most widely prescribed classes of medications for gastroesophageal and laryngopharyngeal reflux diseases. There is emerging evidence that the pathogenesis of disease in laryngeal mucosa is not just related to refluxed acid, but also the presence of pepsin and acidic microenvironments. The widespread use of PPIs is also calling into question potential complications of PPI use. This commentary expands upon these issues with other potential unexpected consequences, and considers the importance of determining a proper approach to patient management.
- Subjects
PROTON pump inhibitors; DRUG prescribing; GASTROESOPHAGEAL reflux; MUCOUS membranes; PEPSIN; MEDICAL care
- Publication
Otolaryngology-Head & Neck Surgery, 2009, Vol 141, Issue 5, p564
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1016/j.otohns.2009.08.027