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- Title
Putative Cell Adhesion Membrane Protein Vstm5 Regulates Neuronal Morphology and Migration in the Central Nervous System.
- Authors
A-Ram Lee; Kwang Woo Ko; Hojae Lee; Yi-Seul Yoon; Mi-Ryoung Song; Chul-Seung Park
- Abstract
During brain development, dynamic changes in neuronal membr anesper form critical roles in neuronal morphogenes is and migration to create functional neural circuits. Amongthe proteins that induce membrane dynamics, cell adhesion molecules are important in neuronal membrane plasticity. Here, we report that V-set and transmembrane domain-containing protein 5 (Vstm5), a cell-adhesion-like molecule belonging to the Ig superfamily, was found in mouse brain. Knock-down of Vstm5 in cultured hippocampal neurons markedly reduced the complexity of dendritic structures, as well as the number of dendritic filopodia. Vstm5 also regulates neuronal morphology by promoting dendritic protrusions that later develop into dendritic spines. Using electroporation in utero, we found that Vstm5 overexpression delayed neuronal migration andinducedmultiplebranchesinleadingprocessesduringcorticogenesis. These results indicate thatVstm5isanewcell-adhesion-likemolecule and is critically involved in synaptogenesis and corticogenesis by promoting neuronal membrane dynamics.
- Subjects
CELL adhesion; MEMBRANE proteins; NEURAL circuitry; CELL morphology; CELL migration; CENTRAL nervous system
- Publication
Journal of Neuroscience, 2016, Vol 36, Issue 39, p10181
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0541-16.2016