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- Title
BCR- ABL1 transcript at 3 months predicts long-term outcomes following second generation tyrosine kinase inhibitor therapy in the patients with chronic myeloid leukaemia in chronic phase who failed Imatinib.
- Authors
Kim, Dennis D.; Lee, Honggi; Kamel‐Reid, Suzanne; Lipton, Jeffrey H.
- Abstract
The BCR- ABL1 transcript level at 3 months can predict long-term outcomes following frontline therapy with Imatinib or Dasatinib in chronic myeloid leukaemia ( CML) patients. However, data is lacking for second-generation tyrosine kinase inhibitor (2 GTKI) therapy after Imatinib failure. A total of 112 patients with CML in chronic phase receiving 2 GTKI after Imatinib failure were reviewed. Treatment outcomes including complete cytogenetic ( CCy R), major molecular ( MMR) and molecular response 4·5 (4·5 log reduction of BCR- ABL1 transcript level, MR4·5), treatment failure, progression-free and overall survival ( OS) were compared according to BCR- ABL1 transcript levels at 3 or 6 months, divided into <1% IS, 1-10% IS and ≥10% IS. BCR- ABL1 transcript level at 3 months showed better correlation with OS ( P < 0·001) than that at 6 months ( P = 0·147). Better OS was also observed in the patients achieving <1% IS (100%) and 1-10% IS (100%) than those with ≥10% IS at 3 months (70·6%, P < 0·001). Those with <1% IS showed the best CCyR, MMR and MR4·5 rates; 1-10% IS, intermediate; and ≥10% IS, the lowest CCyR, MMR and MR4·5 rates. The group with <1% IS at 3 months maintained significantly lower BCR- ABL1 transcript level compared to other two groups. In conclusion, the BCR- ABL1 transcript level at 3 months is the most relevant surrogate for outcomes following 2 GTKI therapy after Imatinib failure.
- Subjects
TREATMENT of chronic myeloid leukemia; IMATINIB; THERAPEUTICS research; PROTEIN-tyrosine kinases; DISEASE progression
- Publication
British Journal of Haematology, 2013, Vol 160, Issue 5, p630
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.12187