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- Title
Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia.
- Authors
Ernst, Thomas; Score, Joannah; Deininger, Michael; Hidalgo-Curtis, Claire; Lackie, Peter; Ershler, William B.; Goldman, John M.; Cross, Nicholas C. P.; Grand, Francis H.
- Abstract
We have identified two novel ABL1 fusion genes in two patients with B-cell acute lymphoblastic leukaemia (ALL) associated with a t(3;9)(p12;q34) and a t(5;9)(q23;q34), respectively. Molecular analysis revealed a FOXP1-ABL1 fusion for the t(3;9) and a SNX2-ABL1 fusion for the t(5;9). The fusions were confirmed by specific amplification of the genomic breakpoints using reverse transcription polymerase chain reaction. The identification of ALL with rare ABL1 fusion partners is important because the leukaemia may respond to tyrosine kinase inhibitors in the same way as ALL patients with a classical BCR-ABL1 fusion gene.
- Subjects
REVERSE transcriptase polymerase chain reaction; GENES; B cells; LYMPHOBLASTIC leukemia; POLYMERASE chain reaction; LEUKEMIA
- Publication
British Journal of Haematology, 2011, Vol 153, Issue 1, p43
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2010.08457.x