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- Title
Interleukin-10 protects against blood-induced joint damage.
- Authors
Jansen, Nathalie W. D.; Roosendaal, Goris; Hooiveld, Michel J. J.; Bijlsma, Johannes W. J.; Van Roon, Joël A. G.; Theobald, Matthias; Lafeber, Floris P. J. G.
- Abstract
Despite prophylactic treatment, haemophilia patients suffer from spontaneous joint bleeds, which lead to severe joint damage. Also after joint trauma, an intra-articular haemorrhage can add to joint damage over time. This study evaluated interleukin 10 (IL-10) in the search for possible interventions to prevent or limit the damaging effects of joint bleeds. Human articular cartilage tissue explants were cultured in the presence or absence of 50% v/v blood (or its cellular components) for 4 d (the expected blood load in vivo after a joint haemorrhage), followed by a recovery period of 12 d. Pharmacological dosages of IL-10 reached during treatment (1 or 10 ng/ml) were added. Additionally, cartilage and synovial tissue obtained from joints with end-stage haemophilic arthropathy (HA) were cultured in the presence of IL-10 (10 ng/ml). IL-10 protected cartilage from the damaging effects of blood exposure, measured by its effects on proteoglycan turnover. In addition, IL-10 beneficially influenced cartilage from patients with HA and reduced the production of the inflammatory cytokines IL-1β and tumour necrosis factor-α by haemophilic synovial tissue. Taken together, although effects were obtained in vitro, IL-10 protects against blood-induced joint damage and might be further evaluated as candidate in treatment of tissue damaging effects of joint haemorrhages.
- Subjects
INTERLEUKIN-10; JOINT diseases; TREATMENT of joints abnormalities; HEMORRHAGE complications; HEMOPHILIA treatment; ERYTHROCYTES; CARTILAGE; HEMOPHILIACS; MEDICAL care
- Publication
British Journal of Haematology, 2008, Vol 142, Issue 6, p953
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2008.07278.x