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- Title
SHORT REPORT T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation.
- Authors
Lowe, Eric J.; Turner, Victoria; Handgretinger, Rupert; Horwitz, Edwin M.; Benaim, Ely; Hale, Gregory A.; Woodard, Paul; Wing Leung
- Abstract
Natural killer (NK) cell alloreactivity resulting from killer immunoglobulin-like receptor (KIR) ligand incompatibility improves outcomes in patients receiving extensively T-cell-depleted bone marrow (BM) grafts. Patients with KIR ligand incompatibility are at risk for donor T-cell alloreactivity. We investigated the relative significance of NK-cell and T-cell alloreactivity in 105 paediatric patients who received a minimally T-cell-depleted human leucocyte antigen-non-identical BM transplantation. Donor NK-cell incompatibility did not improve patient outcome [engraftment, graft-versus-host disease (GVHD), relapse or overall survival]. In contrast, donor T-cell incompatibility was a risk factor for acute GVHD, chronic GVHD and death. Thus, T-cell alloreactivity dominated that of NK cells in minimally T-cell-depleted grafts.
- Subjects
BONE marrow; T cells; KILLER cells; LEUCOCYTES
- Publication
British Journal of Haematology, 2003, Vol 123, Issue 2, p323
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2003.04604.x