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- Title
Access to [6‐7‐6]‐Icetexanes through Sequential Cascade Cyclization and Biomimetic Ring Expansion.
- Authors
Le, Thuy Quynh; Liaba, Niaz; Jeong, Da In; Lee, Jeonghyo; Oh, Chang Ho
- Abstract
We herein report an efficient synthetic method for preparing [6‐7‐6]‐icetexane derivatives. This approach employs our previously designed copper‐catalyzed intramolecular cyclization of enyne‐aryl carbonyl substrates to generate a [6‐6‐6]‐tricyclic abietane framework and a subsequent ring expansion protocol for the [6‐7‐6] scaffold. By synergizing these protocols, we established a highly efficient pathway for synthesizing icetexane compounds from readily available enyne‐aryl starting materials, exhibiting remarkable versatility in accommodating various functional groups while delivering consistently high yields.
- Subjects
RING formation (Chemistry); ABIETANE; FUNCTIONAL groups; BIOMIMETIC materials
- Publication
Asian Journal of Organic Chemistry, 2024, Vol 13, Issue 1, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202300545