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- Title
Ligand‐ and Additive‐Free CuCl<sub>2</sub>‐Catalyzed para‐C−H Alkylation of Aniline Derivatives via Carbene Insertion.
- Authors
Gao, Lei; Liu, Sheng; Wang, Zi‐Chao; Mao, Yongjun; Shi, Shi‐Liang
- Abstract
Transition metal‐catalyzed C−H insertion reaction is a straightforward strategy to realize the direct functionalization of electric‐rich (hetero)arenes. The known methods generally require metal catalysts chelating with well‐defined ligands and the use of additives; a simple and practical catalytic system is still needed. We herein report a ligand‐ and additive‐free, CuCl2‐catalyzed highly selective para‐C−H carbene insertion of aniline derivatives using α‐aryl‐α‐diazo esters. A diverse array of 1,1‐diarylacetates were obtained in high yields with excellent chemo‐ and regioselectivity.
- Subjects
ANILINE derivatives; CARBENE derivatives; ALKYLATION; METAL catalysts; CARBENE synthesis; ESTERS; CARBENES; ARYL chlorides
- Publication
Asian Journal of Organic Chemistry, 2022, Vol 11, Issue 2, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202100723