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- Title
Four‐Component Construction of Coumarin‐Fused Pyrrolo[2,1‐a]isoquinoline: Expedient Synthesis of Lamellarins and Their Regioselective Demethylation.
- Authors
Manjappa, Kiran B.; Jhang, Jia‐Wei; Lakshmi, K. C. Seetha; Yang, Ding‐Yah
- Abstract
Construction of the coumarin‐fused pyrrolo[2,1‐a]isolquinoline skeleton was realized through a four‐component reaction between isoquinoline, ethyl bromoacetate, o‐hydroxybenzaldehyde and nitromethane. This methodology was further extended to the synthesis of lamellarin D trimethyl ether and a formal synthesis of lamellarin D. The controlled demethylation of lamellarin D trimethyl ether yielded dihydroxy and tetrahydroxy lamellarin analogues regioselectively.
- Subjects
ISOQUINOLINE synthesis; DEMETHYLATION; ISOQUINOLINE; ETHER synthesis; NITROMETHANE
- Publication
Asian Journal of Organic Chemistry, 2022, Vol 11, Issue 1, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202100659