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- Title
Antiosteoporotic Activity of Dioscorea alata L. cv. Phyto through Driving Mesenchymal Stem Cells Differentiation for Bone Formation.
- Authors
Kang-Yung Peng; Lin-Yea Horng; Hui-Ching Sung; Hui-Chuan Huang; Rong-Tsun Wu
- Abstract
The aim of this study was to evaluate the effect of an ethanol extract of the rhizomes of Dioscorea alata L. cv. Phyto, Dispo85E, on bone formation and to investigate the mechanisms involved. Our results showed that Dispo85E increased the activity of alkaline phosphatase (ALP) and bone nodule formation in primary bone marrow cultures. In addition, Dispo85E stimulated pluripotent C3H10T1/2 stemcells to differentiate into osteoblasts rather than adipocytes. Our in vivo data indicated that Dispo85E promotes osteoblastogenesis by increasing ALP activity and bone nodule formation in both intact and ovariectomized (OVX)mice. Microcomputed tomography (μCT) analysis also showed that Dispo85E ameliorates the deterioration of trabecular bone mineral density (tBMD), trabecular bone volume/total volume (BV/TV), and trabecular bone number (Tb.N) in OVX mice. Our results suggested that Dispo85E is a botanical drug with a novel mechanism that drives the lineage-specific differentiation of bonemarrow stromal cells and is a candidate drug for osteoporosis therapy.
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2011, Vol 8, Issue 1, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2011/712892