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- Title
Long-Term Effects of Local Ionizing Radiation Treatment on Langerhans Cells in Mouse Footpad Epidermis.
- Authors
Cole, Shirley
- Abstract
Langerhans cells (LC) were studied with ADPase histochemistry in sheets of hind footbad epidermis from groups of CBA/H mice. Single, local 20-Gy doses of 250-kV x-rays were administered to the right hind feet of the mice when they were 3-4 months old, and LC were counted at intervals ranging from 2 to 24 months later. In unirradiated mice, aged 5-19 months, them ean density of LC in footpad was 1521-1617 cells/ mm2. It dropped to 1137 ± 86 cells/ mm2 (mean ± SE) in untreated 28-month-old mice. At times from 2-15 months after irradiation, normal mean densities of LC were present in footpad epidermis. On average, LC numbers were subsequently reduced to 1078 ± 65/ mm2 by 19 months after irradiation (71% of the cells in age-matched controls) and to 789 ± 53/ mm2 by 24 months (59% of the cells in age-matched controls). Loss of cells was focal. Chronic radiation-induced fibrosis and dmaage to circulatory function in skin may have contributed to impaired replacement of LC from bone arrow precursors. The possibility that late radiation-related depletion of the LC population permits development of skin tumors as a delayed consequence of exposure to ionizing radiation is discussed.
- Subjects
LANGERHANS cells; IONIZING radiation; EPIDERMIS; IA antigens; IMMUNOGLOBULINS; DENDRITIC cells
- Publication
Journal of Investigative Dermatology, 1986, Vol 87, Issue 5, p608
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12455853