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- Title
Protective Effects of Caffeic Acid Phenethyl Ester on Isoniazid and Rifampicin-induced Hepatic and Pancreatic Injury.
- Authors
Turkcu, G.; Avci, Y.; Evliyaoglu, O.; Gokalp, O.; Gumus, M.; Tanrikulu, A. C.; Abakay, A.; Buyukbayram, H.; Firat, U.
- Abstract
Objective: To investigate the protective effects of caffeic acid phenethyl ester (CAPE) against isoniazid (INH)- and rifampicin (RFP)-induced hepatic and pancreatic damage. Methods: Eighty adult rats were randomly divided into eight groups: control, INH, RFP, INH+RFP, INH+CAPE, RFP+CAPE, INH+RFP+CAPE, and CAPE. Both INH and RFP were orally administered for 30 days at a dose of 50 mg/kg/day. Caffeic acid phenethyl ester was intraperitoneally injected for 30 days (10 µmol/kg). Blood samples, hepatic and pancreatic tissues were obtained on day 30. Results: Total oxidant status levels were significantly higher in INH and/or RFP-treated groups than those of control and CAPE groups, while total antioxidant status and paraoxonase levels were significantly reduced in INH-RFP groups compared with the group receiving CAPE. Histopathological deterioration was observed in RFP and INH groups in pancreatic and hepatic tissue. However, significant amelioration was observed in CAPE-treated groups. Conclusion: Our findings suggest that CAPE may be a promising agent to prevent the side effects of INH and RFP treatment on hepatic and pancreatic tissues.
- Subjects
CAFFEIC acid; OXIDANT status; ISONIAZID; ESTERS; HISTOPATHOLOGY; ADULTS
- Publication
West Indian Medical Journal, 2021, Vol 69, Issue 5, p350
- ISSN
0043-3144
- Publication type
Article
- DOI
10.7727/wimj.2015.561