We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
EVALUATION OF RECOVERY FROM ACUTE LUNG INJURY INDUCED BY INTRATRACHEAL INSTILLATION OF ZINC OXIDE NANOPARTICLES.
- Authors
YOO, J.; SEO, G. B.; YOON, B. I.; LIM, Y. M.; KIM, P.; KIM, H. M.; KWON, J. T.
- Abstract
Zinc oxide nanoparticles (ZnO-NPs) can potentially cause adverse health effects because they are highly soluble and widely used. We evaluated the effect of ZnO-NPs in rat lung. ZnO-NPs were administered via intratracheal instillation to Sprague Dawley rats at three different dosages (1, 5, and 10 mg/kg body weight). Macrophage numbers, total cell count, and total protein concentrations in bronchoalveolar lavage fluid (BALF) highly increased at day 1 in a dose-dependent manner relative to those in the control. Macrophage numbers and total protein concentrations were still elevated at day 14 relative to baseline, whereas total cell number continued to increase. These results indicate that inflammation had not fully resolved by day 14 in rat lungs. Furthermore, a significant increase in IL-6 (but not TNF-α) was observed in 5 and 10 mg/kg dose groups at day 1, which was likely caused by a ZnO-NP-treatment-induced increase in polymorphonuclear leukocytes. Histological examination indicated that multifocal acute inflammation occurred in the ZnO-NP-treated groups and progressed to chronic inflammation by day 14. A partial recovery of lung injury was observed within 14 days after exposure. In conclusion, the results of this study were consistent with those of previous sub-chronic exposure studies.
- Subjects
LUNG injuries; ZINC oxide; NANOPARTICLES; SPRAGUE Dawley rats; MACROPHAGES
- Publication
Applied Ecology & Environmental Research, 2018, Vol 16, Issue 3, p3145
- ISSN
1589-1623
- Publication type
Article
- DOI
10.15666/aeer/1603_31453157