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- Title
Evaluation of antimicrobial effect of azadirachtin plant extract (Soluneem (™)) on commonly found root canal pathogenic microorganisms (viz. Enterococcus faecalis) in primary teeth: A microbiological study.
- Authors
Shah, Shanal; Venkataraghavan, Karthik; Choudhary, Prashant; Mohammad, Shameer; Trivedi, Krishna; Shah, Shalin G.
- Abstract
<bold>Aim: </bold>The aim of this study is to evaluate the antimicrobial activity of Soluneem ™ when used as an irrigating solution along with other commonly used irrigating solution sodium hypochlorite (NaOCl) against Enterococcus faecalis.<bold>Materials and Methods: </bold>Microorganism used in this study was E. faecalis (Microbial Type Culture Collection 439). Test substance used was Soluneem ™, which was obtained from Vittal Mallya Scientific Research Foundation (VMSRF), Bengaluru. This study was conducted in a microbiology laboratory (Biocare Research India Pvt., Ltd. Laboratory, Ahmedabad, Gujarat) to evaluate the antimicrobial effect of Soluneem ™ (Azadirachtin) on E. faecalis. Antimicrobial activity testing was performed using the macrobroth dilution method according to the Clinical Laboratory Standards Institute guidelines. All determinations were performed thrice.<bold>Results: </bold>Minimum bactericidal concentration (MBC) was seen as 2.6% for Soluneem ™ while the same was seen at 0.1% for NaOCl. Independent sample t-test was carried out to compare the MBC of Soluneem ™ and NaOCl, which showed that there was no statistically significant difference between them, i.e., 2.6% Soluneem ™ was as effective as 0.1% NaOCl.<bold>Conclusion: </bold>Soluneem ™ showed antimicrobial activity against E. faecalis at various concentrations. It was also found that the efficacy of Soluneem ™ at 2.6% concentration and above was relatively similar to that of gold standard irrigating solution (NaOCl) on inhibition of E. faecalis.
- Subjects
ANTI-infective agents; AZADIRACHTIN; THERAPEUTIC use of plant extracts; DENTAL pulp cavities; ENTEROCOCCUS faecalis; DECIDUOUS teeth; DISEASES; BIOMEDICAL materials; DOSE-effect relationship in pharmacology; ENTEROCOCCUS; HYDROCARBONS; INDICATOR dilution; MICROBIAL sensitivity tests; PLANTS; SEEDS; PLANT extracts; PHARMACODYNAMICS
- Publication
Journal of the Indian Society of Pedodontics & Preventive Dentistry, 2016, Vol 34, Issue 3, p210
- ISSN
0970-4388
- Publication type
journal article
- DOI
10.4103/0970-4388.186741