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- Title
Study of aerobic granulocyte functional activity in the presence of a radiosensitizer (metronidazole).
- Authors
Al-Krawi, E. A. A.; Al-Hashimi, A. H. M.
- Abstract
The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear (PMN) cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. At therapeutic doses of metronidazole (4.98-24.86 µg/mL) significant inhibition of the production of reactive oxygen species was noted in both methods. The inhibitory effect was in a dose-dependent pattern. The data suggest a scavenging mechanism of metronidazole on reactive oxygen species generated by PMN.
- Subjects
METRONIDAZOLE; REACTIVE oxygen species; NITROBLUE tetrazolium; CHEMILUMINESCENCE; DRUG dosage
- Publication
Eastern Mediterranean Health Journal, 2009, Vol 15, Issue 1, p224
- ISSN
1020-3397
- Publication type
Article
- DOI
10.26719/2009.15.1.224