We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Overlapping Drug-Eluting Stent Is Associated with Increased Definite Stent Thrombosis and Revascularization: Results from 15,561 Patients in the AUTHENTIC Study.
- Authors
Chen, Xiang; Gao, Xiaofei; Kan, Jing; Shrestha, Rajiv; Han, Leng; Lu, Shu; Qian, Xuesong; Gogas, Bill D.; Zhang, Junjie; Chen, Shao-Liang
- Abstract
Purpose: This study was to analyze the incidence of definite stent thrombosis (ST) after the implantation of drug-eluting stents (DESs) and cutoff value of overlapping length for predicting definite ST. An overlapping stent is associated with a high rate of clinical events after DES implantation compared with a non-overlapping stent. However, the rates of definite ST and clinical outcomes from a large patient population remain underreported. Methods: A total of 15,561 patients with 24,183 lesions who underwent DES implantation from January 2005 to February 2017 were retrospectively included in 5 tertiary hospitals in China. The main endpoint was the incidence of definite ST after procedures. Results: With a median of 1932 (IQR = 1194–2929) days, clinical follow-up was available in 7484 patients in the overlap group and in 8077 patients in the non-overlap group. The rates of definite ST were 3.1% in the overlap group and 1.2% in the non-overlap group (HR: 2.67 (95% CI: 2.11–3.38), p < 0.001). Of the 24,183 treated lesions, the incidences of definite ST were 2.4% in the overlap group and 0.9% in the non-overlap group (HR: 2.96 (95% CI: 2.38–3.69), p < 0.001). Stent overlap was associated with a higher rate of target lesion revascularization (TLR) (9.4%) compared with stent non-overlap (6.4%, p < 0.001). The length of overlapping stent ≥ 2.93 mm strongly correlated with definite ST. Conclusion: The present study shows that overlapping DES increases definite ST and revascularization in patients during long-term follow-up. In addition, the longer overlapping zone was associated with worse clinical outcomes.
- Subjects
CHINA; THROMBOSIS; REFERENCE values; TREATMENT effectiveness; DRUG-eluting stents
- Publication
Cardiovascular Drugs & Therapy, 2021, Vol 35, Issue 2, p331
- ISSN
0920-3206
- Publication type
Article
- DOI
10.1007/s10557-020-07094-7