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- Title
Extended criteria donor lung reconditioning with the organ care system lung: a single institution experience.
- Authors
Schiavon, Marco; Rebusso, Alessandro; Comacchio, Giovanni; Marulli, Giuseppe; Federico, Rea; Faggi, Giulio; Lunardi, Francesca; Calabrese, Fiorella; Di Gregorio, Guido; Feltracco, Paolo; Gregori, Dario; Cozzi, Emanuele
- Abstract
Summary: Lung transplantation is a life‐saving procedure limited by donor's availability. Lung reconditioning by ex vivo lung perfusion represents a tool to expand the donor pool. In this study, we describe our experience with the OCS™ Lung to assess and recondition extended criteria lungs. From January 2014 to October 2016, of 86 on‐site donors evaluated, eight lungs have been identified as potentially treatable with OCS™ Lung. We analyzed data from these donors and the recipient outcomes after transplantation. All donor lungs improved during OCS perfusion in particular regarding the PaO2/FiO2 ratio (from 340 mmHg in donor to 537 mmHg in OCS) leading to lung transplantation in all cases. Concerning postoperative results, primary graft dysfunction score 3 at 72 h was observed in one patient, while median mechanical ventilation time, ICU, and hospital stay were 60 h, 14 and 36 days respectively. One in‐hospital death was recorded (12.5%), while other two patients died during follow‐up leading to 1‐year survival of 62.5%. The remaining five patients are alive and in good conditions. This case series demonstrates the feasibility and value of lung reconditioning with the OCS™ Lung; a prospective trial is underway to validate its role to safely increase the number of donor lungs.
- Publication
Transplant International, 2019, Vol 32, Issue 2, p131
- ISSN
0934-0874
- Publication type
Article
- DOI
10.1111/tri.13365