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- Title
Improvement of gagCEST imaging in the human lumbar intervertebral disc by motion correction.
- Authors
Müller-Lutz, Anja; Schleich, Christoph; Schmitt, Benjamin; Topgöz, Melike; Pentang, Gael; Antoch, Gerald; Wittsack, Hans-Jörg; Miese, Falk
- Abstract
Objective: To investigate whether motion correction improves glycosaminoglycan chemical exchange saturation transfer imaging (gagCEST imaging) of intervertebral discs (IVDs). Materials and methods: Magnetic resonance gagCEST imaging of 12 volunteers was obtained in lumbar IVDs at 3 T using a prototype pulse sequence. The data were motion-corrected using a prototype diffeomorphism-based motion compensation technique. For both the data with and that without motion correction (data, data), CEST evaluation was performed using the magnetisation transfer ratio asymmetry (MTR) as a means of quantifying CEST effects. MTR and the signal-to-noise ratio (SNR) of the MTR map in the nucleus pulposus (NP) were compared for data and data. A visual grading analysis was performed by a radiologist in order to subjectively quantify the quality of the MTR analysis (score 1: best quality, score 5: worst quality). Furthermore, a landmark analysis was performed in order to objectively quantify the motion between CEST images using the mean landmark distance d. Results: MTR and SNR were significantly higher for the motion-corrected data than for the uncorrected CEST data (MTR(data) = 3.77 % ± 0.95 %, MTR(data) = 3.41 % ± 1.54 %, p value = 0.001; SNR(data) = 3.88 ± 2.04, SNR(data) = 2.77 ± 1.55, p value < 0.001, number of IVDs = 48). The visual grading analysis revealed a higher reliability for data (maximum score = 2) compared with data (maximum score = 5). The landmark analysis demonstrated the superiority of the motion-corrected data (d(data) =0.08 mm ±0.09 mm, d(data) = 0.36 mm ±0.09 mm, p value = 0.001). Conclusion: Our study showed significant improvements in the ability to quantify CEST imaging in IVDs after the application of motion correction compared with uncorrected datasets.
- Subjects
INTERVERTEBRAL disk radiography; LUMBAR vertebrae; IMAGE stabilization; GLYCOSAMINOGLYCANS; NUCLEUS pulposus
- Publication
Skeletal Radiology, 2015, Vol 44, Issue 4, p505
- ISSN
0364-2348
- Publication type
Article
- DOI
10.1007/s00256-014-2034-z