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- Title
Synthesis of Polysubstituted Enamides by Hydrogen Atom Transfer Alkene Isomerization Using Dual Cobalt/Photoredox Catalysis.
- Authors
Seino, Yusuke; Yamaguchi, Yuto; Suzuki, Akihiko; Yamashita, Masaaki; Kamei, Yuji; Kamiyama, Futa; Yoshino, Tatsuhiko; Kojima, Masahiro; Matsunaga, Shigeki
- Abstract
M‐HAT isomerization is a highly reliable method to access thermodynamically stable alkenes with high functional group tolerance. However, synthesis of heteroatom‐substituted alkenes by M‐HAT isomerization reaction is still underdeveloped. Herein, we report an enamide synthesis using M‐HAT via a combination of cobalt and photoredox catalysis. This method tolerates a variety of functional groups including haloarenes, heteroarenes, free hydroxy groups, non‐protected indoles, and drug derivatives. Furthermore, this method can isomerize styrene derivatives in good yield and E/Z selectivity.
- Subjects
ISOMERIZATION; ALKENES; COBALT; STYRENE derivatives; DRUG derivatives; ABSTRACTION reactions
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 37, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202300804