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- Title
A Rare Alder‐ene Cycloisomerization of 1,6‐Allenynes.
- Authors
Joyce, Liam M.; Drew, Melanie A.; Tague, Andrew J.; Thaima, Thanaphat; Gouranourimi, Ali; Ariafard, Alireza; Pyne, Stephen G.; Hyland, Christopher J. T.
- Abstract
Thermally induced cycloisomerization reactions of 1,6‐allenynes gives α‐methylene‐γ‐lactams via intramolecular Alder‐ene reactions. The mechanism is supported by computational and deuterium labelling studies. This thermal, non‐radical method enables the discovery of a hitherto unknown route that proceeds via a divergent mechanism distinct from the previous [2+2] cycloisomerization manifold.
- Subjects
CYCLOISOMERIZATION; ENE reactions; DEUTERIUM
- Publication
Chemistry - A European Journal, 2022, Vol 28, Issue 12, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202104022