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- Title
FTIR and thermal studies of medicated jellies with topiramate.
- Authors
Budiul, Mihaela Maria; Marioane, Cristina Adela; Bradu, Ionela-Amalia; Vlase, Gabriela; Vlase, Titus
- Abstract
Topiramate or (2,3:4,5-bis-O-methylethylidene-β-d-fructopyranose sulfamate) is classified as a sulfamate-substituted monosaccharide derived from fructose and is one of the most efficient antiepileptic drugs. Oral medicated jelly is an easily swallowed dosage form for administration to dysphagic patients including pediatrics or geriatrics. For this study, medicated jellies with topiramate were developed and characterized employing currently used gelling agents: sodium alginate, gelatin and pectin. Moist binary mixtures between topiramate and each component used in jellies were prepared before the jellies formulations to determine the substance compatibility. Topiramate, moist binary mixtures and oral medicated jellies were analyzed by FTIR–UATR spectroscopy, UV–Vis spectroscopy and thermogravimetry to evaluate the thermal behavior and possible interactions between compounds.
- Subjects
TOPIRAMATE; JELLY; SODIUM alginate; ANTICONVULSANTS; PECTINS; BINARY mixtures; ULTRAVIOLET-visible spectroscopy; MONOSACCHARIDES
- Publication
Journal of Thermal Analysis & Calorimetry, 2023, Vol 148, Issue 10, p4589
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-022-11882-8