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- Title
Increased levels of lipoprotein(a) in non-smoking aortic dissection patients.
- Authors
Xiao-feng Chen; Li-jiang Tang; Jian-jun Jiang; Jun Jiang; Xin-yang Hu; Wei-fang Yu; Jian-an Wang
- Abstract
To investigate lipoprotein(a) (Lp(a)) serum levels in patients with aortic dissection and the influence of smoking on the level of Lp(a) in aortic dissection patients. An age-and sex-matched case-control study was conducted. Lp(a) levels in patients with aortic dissection ( n = 52) and healthy subjects ( n = 104) were studied. The strength of associations between Lp(a) serum levels and aortic dissection was assessed by means of multivariate logistic regression analysis. Patients with aortic dissection had significantly higher Lp(a) serum levels (median, 17.6 mg/dl; range, 6.4–88.7 mg/dl) compared to healthy individuals (median, 12.4 mg/dl; range, 4.9–26.4 mg/dl) ( p = 0.005). The Lp(a) concentration in non-smoking patients with aortic dissection (median, 19.1 mg/dl, range, 10.5–88.7 mg/dl) significantly surpassed that of the smoking patients with aortic dissection of comparable age (median, 10.7 mg/dl; range, 6.4–22.1 mg/dl) ( p < 0.0001). Multivariate analysis confirmed an independent association between Lp(a) and aortic dissection in the non-smoking population ( p = 0.001). Serum Lp(a) level is significantly elevated in non-smoking patients with aortic dissection independently of other cardiovascular risk factors. Therefore, determination of Lp(a) levels may be important in identifying subjects at risk of aortic dissection among nonsmokers.
- Subjects
AORTIC dissection; AORTIC aneurysms; LIPOPROTEIN A; LIPIDS; SMOKING
- Publication
Clinical & Experimental Medicine, 2008, Vol 8, Issue 2, p123
- ISSN
1591-8890
- Publication type
Article
- DOI
10.1007/s10238-008-0167-x