We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The role of angiogenesis in prostate development and the pathogenesis of prostate cancer.
- Authors
Hrouda, David; Nicol, David Leslie; Gardiner, Robert Alexander
- Abstract
New vessel formation, a highly-regulated, active process commencing in the embryo and evident notably during the pubertal growth spurt, is essential for normal prostate development. Reactivation of this process in response to physiological stimuli, particularly hypoxia in mature tissues, occurs with new vessels forming principally from stromal components. Although angiogenesis is complex, putatively involving a multitude of angiogenic factors and inhibitors, there is powerful evidence of the importance of the VEGF system in the development of both the normal prostate and prostate cancer. Recent advances include an understanding of how castration acts through the VEGF system to inhibit angiogenesis. Stromal-endothelial and epithelial-endothelial interactions are just beginning to be investigated. A better understanding of how physiological angiogenesis is controlled should help to provide further insights into the mechanism of disregulated angiogenesis in tumours. Ultimately, new antiangiogenic agents are likely to find a role in the management of patients with prostate cancer.
- Subjects
PROSTATE cancer; NEOVASCULARIZATION; CANCER research; PHYSIOLOGY; MOLECULAR biology; BIOCHEMISTRY
- Publication
Urological Research, 2003, Vol 30, Issue 6, p347
- ISSN
0300-5623
- Publication type
Article
- DOI
10.1007/s00240-002-0287-9