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- Title
Clinical features of patients with infections caused by Candida guilliermondii and Candida fermentati and antifungal susceptibility of the isolates at a medical centre in Taiwan, 2001–10.
- Authors
Chen, Chien-Yuan; Huang, Shang-Yi; Tang, Jih-Luh; Tsay, Woei; Yao, Ming; Ko, Bo-Sheng; Chou, Wen-Chien; Tien, Hwei-Fang; Hsueh, Po-Ren
- Abstract
Objectives This study was intended to analyse the clinical characteristics and outcomes of patients with infections due to Candida guilliermondii complex and evaluate in vitro susceptibilities of the isolates. Methods We searched the Mycology Database of the National Taiwan University Hospital and identified patients with infections due to C. guilliermondii complex from 2001 to 2010. Isolates were identified to species level by two yeast identification systems and restriction fragment length polymorphism of the riboflavin synthetase gene. MICs of nine antifungal agents were determined using the Sensititre YeastOne system (Trek Diagnostic Systems) and were interpreted by breakpoints (BPs) for three echinocandins and epidemiological cut-off values (ECVs) for the other agents. Results Fifty-two patients with infections due to C. guilliermondii complex were evaluated. The majority (90%, n = 47) of the isolates were C. guilliermondii, followed by Candida fermentati (10%, n = 5). Among them, 42 (81%) were isolated from blood cultures. Among the 52 patients, 27 (52%) had underlying malignancy and 15 (29%) had undergone abdominal surgery. The 30 day mortality rates among patients with C. guilliermondii and C. fermentati infections were 45% and 60%, respectively. Among C. guilliermondii isolates, 98%, 100% and 98% were susceptible to caspofungin, micafungin and anidulafungin, respectively, by BPs. Nearly all (96%–100%) C. guilliermondii isolates belonged to wild-type for the other agents by ECVs. All five C. fermentati were susceptible to three echinocandins and belonged to wild-type for the other agents. Conclusions The currently used antifungal agents exhibited good in vitro activities against C. guilliermondii complex isolates.
- Subjects
HEALTH outcome assessment; INFECTION; CANDIDA; ANTIFUNGAL agents; GENETIC polymorphisms
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2013, Vol 68, Issue 11, p2632
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkt214