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- Title
Is topical fluorescein that effective in endoscopic CSF leak closure?
- Authors
Eren, Erdem; Güvenç, Gönül; İşlek, Akif; Arslanoğlu, Seçil; Önal, Kazım; Yüceer, Nurullah
- Abstract
Purpose: Several diagnostic modalities are used to detect CSF leaks. Intraoperative use of intrathecal fluorescein can help to detect and localize a CSF leak simultaneously. However, it is not FDA approved, the application is invasive and has serious complications. Topical fluorescein is reported to be a safe and sensitive alternative to ITF. In this study, we aimed to evaluate the effectiveness of topical fluorescein in CSF leak closure. Methods: This retrospective study includes 27 consecutive patients (19 women, 8 men) who underwent endoscopic endonasal CSF leak closure using topical fluorescein, between 2011 and 2017. Results: In two patients, radiologic studies false positively locate the defect. β2 transferrin and topical fluorescein tests were positive in these patients. Both cases needed a second operation. Conclusion: If radiologic studies fail to locate the defect properly, topical fluorescein only confirms the CSF leak, but the defect cannot be located anatomically intraoperatively.
- Subjects
INTERNATIONAL Tennis Federation; UNITED States. Food &; Drug Administration; FLUORESCEIN; TRANSFERRIN
- Publication
European Archives of Oto-Rhino-Laryngology, 2020, Vol 277, Issue 4, p1073
- ISSN
0937-4477
- Publication type
Article
- DOI
10.1007/s00405-019-05766-1