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- Title
Biochemistry: Radicals by reduction.
- Authors
Jarrett, Joseph T.
- Abstract
The article examines the significance of radicals. It is stated that radicals are often generated by enzymes to overcome chemically difficult problems. Radicals can react rapidly with DNA, proteins and lipids when they are generated within an organism causing chemical modifications known as oxidative damage. The reactivity of radicals can also be harnessed to promote various important biochemical transformations when organic radicals are formed within an enzyme active site. Moreover, organic radicals have gained acceptance as plausible reaction intermediates for biochemical reactions.
- Subjects
RADICALS (Chemistry); ENZYMES; CHEMICAL reactions; DNA; PROTEINS; LIPIDS; REACTIVITY (Chemistry); INTERMEDIATES (Chemistry); BIOCHEMISTRY
- Publication
Nature, 2008, Vol 452, Issue 7184, p163
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/452163a