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- Title
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis.
- Authors
Moynahan, Mary Ellen; Jasin, Maria
- Abstract
Mitotic homologous recombination promotes genome stability through the precise repair of DNA double-strand breaks and other lesions that are encountered during normal cellular metabolism and from exogenous insults. As a result, homologous recombination repair is essential during proliferative stages in development and during somatic cell renewal in adults to protect against cell death and mutagenic outcomes from DNA damage. Mutations in mammalian genes encoding homologous recombination proteins, including BRCA1, BRCA2 and PALB2, are associated with developmental abnormalities and tumorigenesis. Recent advances have provided a clearer understanding of the connections between these proteins and of the key steps of homologous recombination and DNA strand exchange.
- Subjects
GENOMES; GENETIC recombination; CARCINOGENESIS; DNA repair; SOMATIC cells; CELL proliferation; DNA damage
- Publication
Nature Reviews Molecular Cell Biology, 2010, Vol 11, Issue 3, p196
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2851