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- Title
Regulation of muscular contractions in the human Fallopian tube through prostaglandins and progestagens.
- Authors
K. Wånggren; A. Stavreus-Evers; C. Olsson; E. Andersson; K. Gemzell-Danielsson
- Abstract
BACKGROUND Transport of gametes and embryos is an important function of the Fallopian tube. Both muscular contractions and cilia activity are involved in the transportation. Prostaglandins (PGs) are known mediators of muscular contractility. PG receptors have previously been demonstrated in the human Fallopian tube. The aim was to study the effect of PGs and progestagens, antiprogestin, hCG and oxytocin on muscular contractions in the human Fallopian tube, and the hormonal regulation of PG receptors. METHODS Twenty-two healthy women operated for benign causes were included in the study. The ampullary-isthmic junction of the Fallopian tubes was excised and used for in vitro contractility studies. The effect of PGE1, PGE2, PGF2α, progesterone, mifepristone, levonorgestrel, oxytocin and hCG on contractility was studied. Explants of Fallopian tubes were cultured for 24 h to study the effect of progestagens and hCG on the expression of PG receptors using immunohistochemistry and real-time PCR. RESULTS Muscular contractions increased after treatment with PGF2α and PGE2 (P 1, progesterone, levonorgestrel, mifepristone, oxytocin and hCG (P P CONCLUSIONS These data suggest that the transport of gametes and embryos involves the action of PGs, progesterone, oxytocin and hCG on muscular contractility.
- Subjects
REGULATION of muscle contraction; FALLOPIAN tubes; PROSTAGLANDINS; PROGESTATIONAL hormones; GAMETES; OXYTOCIN
- Publication
Human Reproduction, 2008, Vol 23, Issue 10, p2359
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/den260