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- Title
Rapid ELISA D-Dimer Testing in the Exclusion of Venous Thromboembolism in Hospitalized Patients.
- Authors
Freyburger, Geneviève; Trillaud, Hervé; Labrouche, Sylvie; Gauthier, Pascal; Javorschi, Sandrine; Grenier, Nicolas
- Abstract
The clinical diagnosis of deep-vein thrombosis (DVT) and pulmonary embolism (PE) is known to be unreliable. Until now, no biological marker has been found lo confirm thrombosis, but help can be gained from a biological Starker ruling out the diagnosis of DVT or PE, i.e.. the sensitive measurement of D-dimer (DD) species. This article summarizes our experience in introducing a rapid D-dimer test (ELISA VIDAS D-dimères test, bioMérieux) in a collaborative strategy for thrombosis diagnosis during 9 consecutive months involving 1,131 measurements. The efficacy of the DD test was very different according the type of patient, and departments where the DD test provides a real diagnostic benefit were identified. High clinical probability for thrombosis was encountered in 32 patients and radiology was carried out, although D-dimer was negative: none of these patients was found to have a thrombosis after radiologic examination. However, extensive progress must be made in test prescription to reduce the excessive rate of positive D-dimer tests (78%) and positive measurements that are not followed up by radiology (42%).
- Subjects
THROMBOSIS; CARDIOVASCULAR diseases; BIOMARKERS; PULMONARY embolism; PATIENTS
- Publication
Clinical & Applied Thrombosis/Hemostasis, 2000, Vol 6, Issue 2, p77
- ISSN
1076-0296
- Publication type
Article
- DOI
10.1177/107602960000600205