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- Title
Cytotoxic Induction and Photoacoustic Imaging of Breast Cancer Cells Using Astaxanthin-Reduced Gold Nanoparticles.
- Authors
Bharathiraja, Subramaniyan; Manivasagan, Panchanathan; Yun-Ok Oh; Junghwan Oh; Nhat Quang Bui; In Gweon Lim; Suhyun Park
- Abstract
Astaxanthin, a kind of photosynthetic pigment, was employed for gold nanoparticle formation. Nanoparticles were characterized using Ulteraviolet-Visible (UV-Vis) spectroscopy, transmission electron microscopy, and X-ray diffraction, and the possible presence of astaxanthin functional groups were analyzed by Fourier transform infrared spectroscopy (FTIR). The cytotoxic effect of synthesized nanoparticles was evaluated against MDA-MB-231 (human breast cancer cells) using a tetrazolium-based assay, and synthesized nanoparticles exhibited dose-dependent toxicity. The morphology upon cell death was differentiated through fluorescent microscopy using different stains that predicted apoptosis. The synthesized nanoparticles were applied in ultrasound-coupled photoacoustic imaging to obtain good images of treated cells. Astaxanthin-reduced gold nanoparticle has the potential to act as a promising agent in the field of photo-based diagnosis and therapy.
- Subjects
ASTAXANTHIN; GOLD nanoparticles; BREAST cancer diagnosis
- Publication
Nanomaterials (2079-4991), 2016, Vol 6, Issue 4, p78
- ISSN
2079-4991
- Publication type
Article
- DOI
10.3390/nano6040078