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- Title
Human genetic susceptibility to infectious disease.
- Authors
Chapman, Stephen J.; Hill, Adrian V. S.
- Abstract
Recent genome-wide studies have reported novel associations between common polymorphisms and susceptibility to many major infectious diseases in humans. In parallel, an increasing number of rare mutations underlying susceptibility to specific phenotypes of infectious disease have been described. Together, these developments have highlighted a key role for host genetic variation in determining the susceptibility to infectious disease. They have also provided insights into the genetic architecture of infectious disease susceptibility and identified immune molecules and pathways that are directly relevant to the human host defence.
- Subjects
HUMAN genetics; COMMUNICABLE diseases; GENETICS of disease susceptibility; HUMAN immunogenetics; GENETIC mutation; PHENOTYPES; DISEASE risk factors
- Publication
Nature Reviews Genetics, 2012, Vol 13, Issue 3, p175
- ISSN
1471-0056
- Publication type
Article
- DOI
10.1038/nrg3114