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- Title
Chemical Composition, Antioxidant and Anti-tumor Activities of the Aerial Parts of Cometes abyssinica R.Br. ex Wall.
- Authors
Abdelgawad, Ahmed A. M.
- Abstract
An in vitro bioassay-guide revealed that the methanolic extract of the aerial parts of Cometes abyssinica had considerable inhibitory activity against colon (HCT-116) and hepatocellular (HepG2) carcinoma cell lines with IC50 24.4 and 29.9 µg/mL, respectively, compared to the drug reference Cisplatin. On the other hand, all studied extracts exhibited weak antioxidant activities using the DPPH scavenging assay with IC50 values between 543-826.4 µg/mL. Phytochemical investigation of the methanol and ethyl acetate extracts of C. abyssinica led to the isolation of five flavonoid compounds: Formononetin 1, Daidzein 2, Eriodictyol 3, Taxifolin 4, and kaempferitrin 5. The chemical structure of the isolated compounds was identified based on their physicochemical and spectroscopic analyses.
- Subjects
ANTINEOPLASTIC agents; PHYTOCHEMICALS; ANTIOXIDANTS; FLAVONOIDS; CHEMICAL structure; PHYTOESTROGENS; CISPLATIN; ETHYL acetate
- Publication
Indian Journal of Pharmaceutical Education & Research, 2023, Vol 57, Issue 2, p459
- ISSN
0019-5464
- Publication type
Article
- DOI
10.5530/ijper.57.2.56