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- Title
Ambient Ultraviolet Radiation and Sebaceous Carcinoma Incidence in the United States, 2000–2016.
- Authors
Sargen, Michael R; Mai, Zhi-Ming; Engels, Eric A; Goldstein, Alisa M; Tucker, Margaret A; Pfeiffer, Ruth M; Cahoon, Elizabeth K
- Abstract
Sebaceous carcinoma (SC) is an aggressive skin tumor. Although ultraviolet radiation (UVR) is an important risk factor for some skin cancer types, no population-level study has evaluated for an association between UVR and SC risk. Herein, we examined satellite-based ambient UVR in relation to SC incidence using Surveillance, Epidemiology, and End Results 18 cancer registry data (2000–2016). There were 3503 microscopically confirmed cases of SC diagnosed during the study period. For non-Hispanic whites, there was an association between increasing ambient UVR and SC risk (incidence rate ratio [per UVR quartile] = 1.15, 95% confidence interval = 1.11 to 1.19; two-sided P < .001) including among individuals with and without putative Muir-Torre syndrome. In contrast, there was no association between ambient UVR and SC risk for other race and ethnicities. Our findings support a role for UVR in SC tumorigenesis, which suggests that photoprotection may reduce SC risk, particularly for high-risk populations (eg, Muir-Torre syndrome).
- Subjects
SEBACEOUS gland tumors; RISK factors of skin cancer; ULTRAVIOLET radiation; SKIN tumors; MUIR-Torre syndrome; CONFIDENCE intervals
- Publication
JNCI Cancer Spectrum, 2020, Vol 4, Issue 2, p1
- ISSN
2515-5091
- Publication type
Article
- DOI
10.1093/jncics/pkaa020