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- Title
Effect of lifelong coenzyme Q10 supplementation on age-related oxidative stress and mitochondrial function in liver and skeletal muscle of rats fed on a polyunsaturated fatty acid (PUFA)-rich diet.
- Authors
Ochoa JJ; Quiles JL; López-Frías M; Huertas JR; Mataix J; Warner HR; Ochoa, Julio J; Quiles, José L; López-Frías, Magdalena; Huertas, Jesús R; Mataix, José
- Abstract
This study investigates aging-related changes in lipid peroxidation and functionality in liver and skeletal-muscle mitochondria in rats fed a diet rich in polyunsaturated fatty acids (PUFA), depending on supplementation or not with coenzyme Q(10) (CoQ(10)). Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with CoQ(10). At 6 and 24 months mitochondria were analyzed for fatty acid profile; hydroperoxides; alpha-tocopherol; CoQ(9;) CoQ(10;) cytochromes b, c+c(1), and a+a(3) contents; cytochrome c oxidase activity; and catalase activity in cytosol. Results of this study showed for the supplemented group an age-associated decrease in the peroxidizability index, an increase in catalase activity in skeletal muscle, and modulation of the aging-related changes in different mitochondrial electron-transport-chain components in skeletal muscle. These findings provide mechanisms to explain the effect of CoQ(10) in extending the life span of animals fed a PUFA-rich diet.
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2007, Vol 62, Issue 11, p1211
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/62.11.1211