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- Title
Evaluation of Bioactive Compounds in Different Extracts of Linum usitatissimum and their Antibacterial Properties.
- Authors
Fadzir, Ummu A.; Mokhtar, Khairani I.; Mustafa, Basma E.; Darnis, Deny S.
- Abstract
Background: Antibacterial agents from natural sources have been suggested as alternatives for treating infectious diseases due to their low side effects. Flaxseed (Linum usitatissimum) exhibits some antibacterial properties, but its effects against oral pathogens are poorly understood. This study investigated flaxseed extracts' antibacterial effects against such pathogens. Methods: Non-polar and polar extracts of flaxseed, with n-hexane, dichloromethane (DCM) and methanol (MeOH), were prepared by sequential Soxhlet extraction. All extracts were qualitatively screened through gas chromatography-mass spectrometry to detect bioactive compounds. Antibacterial activities of flaxseed extracts with different volumes per disc (Oxoid, Badhoevedorp, Netherlands) (5, 7, 10, 12 and 15 µL/disc) were evaluated against four different oral pathogens: Streptococcus pyogenes, Streptococcus mutans, Lactobacillus casei and Enterococcus faecalis, using the disc diffusion method. Flaxseed extracts' inhibitory activities against the tested oral pathogens were examined by measuring the inhibition zone diameter. Results: Polar extract (methanolic extract) demonstrated significant antibacterial activity (p<0.01) against all tested oral pathogens, with inhibition zones comparable to those for penicillin. In contrast, n-hexane and DCM extracts demonstrated variable antibacterial activities. Conclusions: This study suggests that Linum usitatissimum methanolic extract exhibited the best inhibitory activity on all tested strains compared to the other extracts.
- Subjects
FLAX; BIOACTIVE compounds; ANTIBACTERIAL agents; PLANT extracts; GAS chromatography/Mass spectrometry (GC-MS); STREPTOCOCCUS pyogenes
- Publication
Makara Journal of Health Research, 2018, Vol 22, Issue 3, p121
- ISSN
2356-3664
- Publication type
Article
- DOI
10.7454/msk.v22i3.10181