We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
High HER2/Centromeric Probe for Chromosome 17 Fluorescence In Situ Hybridization Ratio Predicts Pathologic Complete Response and Survival Outcome in Patients Receiving Neoadjuvant Systemic Therapy With Trastuzumab for HER2-Overexpressing Locally Advanced Breast Cancer.
- Authors
Kogawa, Takahiro; Fouad, Tamer M.; Liu, Diane D.; Wu, Jimin; Shen, Yu; Masuda, Hiroko; Fujii, Takeo; Chavez‐MacGregor, Mariana; Alvarez, Ricardo H.; Hortobágyi, Gabriel N.; Valero, Vicente; Ueno, Naoto T.
- Abstract
Background. The present study was performed to determine whether the human epidermal growth factor receptor-related 2 (HER2)/centromeric probe for chromosome 17 fluorescence in situ hybridization (FISH) ratio is a predictor of a pathologic complete response (pCR), recurrence-free survival (RFS), and/or overall survival (OS) in patients receiving neoadjuvant systemic treatment (NST) with trastuzumab (NST-T) for HER2 1 locally advanced breast cancer (LABC). Patients and Methods. The present retrospective study included 555 patients with HER21 LABC who had undergone NST and definitive surgery (1999-2012); 373 had concurrently received trastuzumab. HER2-positivity was considered present with an immunohistochemical score of 31 and/or HER2 FISH ratio of ≥2.0. We used logistic regression analysis and Cox proportional hazard modeling to determine whether a high HER2 FISH ratio, either as a continuous variable or with a cutoff of ≥7.0, would predict for pCR (no invasive disease in the breast and no tumor in the ipsilateral axillary lymph nodes), RFS, and/or OS. Results. The pCR group's median HER2 FISH ratio was significantly higher than that of the non-pCR group (6.4 vs. 5.2; p = .003). The logistic regression model demonstrated that the independent predictors of pCR included a high HER2 FISH ratio as a continuous variable (p = .04). The multicovariate Cox proportional hazard model showed that a high HER2 FISH ratio (with a cutoff of ≥7.0 or as a continuous variable) was a significant prognostic indicator of longer RFS time (p = .047 and p = .04, respectively). Similarly, a high HER2 FISH ratio of ≥7.0 was associated with longer OS (p = .06). Conclusion. A high HER2 FISH ratio is a predictor of pCR in patients with HER21 LABC who receive NST-T.
- Subjects
TEXAS; BREAST cancer prognosis; BREAST tumors; CHROMOSOMES; COMBINED modality therapy; CONFIDENCE intervals; IMMUNOHISTOCHEMISTRY; ONCOGENES; RESEARCH funding; SURVIVAL analysis (Biometry); SURVIVAL; TRASTUZUMAB; FLUORESCENCE in situ hybridization; LOGISTIC regression analysis; TREATMENT effectiveness; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; ODDS ratio; MANN Whitney U Test; GENETICS
- Publication
Oncologist, 2016, Vol 21, Issue 1, p21
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1634/theoncologist.2015-0101