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- Title
RELATIONSHIP BETWEEN PSA AND THIOL GROUPS.
- Authors
ÇOLAK, Yavuz Selim; BALIK, Ahmet Rıfat; İPTEÇ, Betül ÖZBEK; BİÇER, Cemile; KOZACI, Leyla Didem
- Abstract
Introduction: Thiols are essential and potent anti‐oxidant molecules containing a functional sulfhydryl groups are important anti‐oxidants and essential molecules protecting organism against the harmful effects of reactive oxygen species. Oxidative modification of proteins may affect a variety of cellular functions, and cause cell damage and death or mutations and carcinogenesis. Increased oxidative stress in prostate cancer patients may cause metabolic disturbance and have a role in the aetiopathogenesis of prostate cancergroup protecting organism against the harmful effects of oxidative stress damage. Prostate‐specific antigen (PSA) is widely considered as an important biomarker used for diagnosing prostate cancer. In this study we aim that, investigate the relationship between PSA and thiol groups. Material and Methods: 255 male patients (age; 29‐90) applied to Ankara Ataturk Training and Reserch Hospital between 01.09.2016 and 15.04.2017 were included in this study. Parameters of thiol disulphide homeostasis were measured by colorimetric method on an automatic analyzer. PSA and fPSA were measured by electrochemiluminescence assay. Patients were divided into 3 groups according to PSA result (<4 ng/mL, 4‐10 ng/mL, >10 ng/mL). The results were evaluated with Spearman's correlation in SPSS. Results: There was a weak negative correlation and a significant correlation between native thiol and PSA in only group 3 (r= ‐580; p= 0.001). Discussion: There was a weak negative correlation between PSA with Native Thiol. Native Thiol decreases in oxidative stress and PSA increases in prostate cancer. The result shows that oxidative stress has increased as the risk for prostate cancer increases (for group 3).
- Subjects
PROSTATE-specific antigen; THIOLS; DIAGNOSIS; PROSTATE cancer
- Publication
Ankara Medical Journal, 2017, p48
- ISSN
2148-4570
- Publication type
Abstract