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- Title
Cancer stem cells: the real culprits in cancer? Clinical and therapeutic relevance.
- Authors
Komporaly, Isabela Anda; Stănculeanu, Dana Lucia
- Abstract
Carcinogenesis is a complex phenomenon which involves a portfolio of genetic, epigenetic, biochemical and histological changes, ultimately leading to the development of pathological manifestations. Despite all the significant advancement in the field of cancer research, the obscurity to understand the real mechanism of cancer development is still there. Tumors of various tissues initiate and harbor from a relatively small population of cells known as cancer stem cells (CSCs), which are the main oncogenic driving cells due to their self-renewal ability and potential to redevelop entire tumor heterogenicities and, hence, are an important target for the treatment of human malignancies. CSCs are the main cause for cancer development, metastasis and drug resistance. A number of dysregulated signaling mechanisms, including Notch, Wnt/B-Catenin, JAK/STAT, PI3K/AKTmTOR etc., responsible for carcinogenesis and poor clinical outcomes, have been detected in CSCs. Although known, all these mechanisms must be further investigated, for the moment the outcomes not being satisfactory. Recent developments in cancer research proved the connections between miRNAs and the signalling pathways that drive the oncogenic potential of the CSC. Dysregulated expression and functioning of miRNAs have been considered an important mechanism for CSCs in cancer, as a single miRNA can control the expression of multiple genes. In this presentation, we are discussing whether the CSCs are the real culprits in carcinogenesis, which are the roles of the signalling pathways and of miRNAs in regulating CSCs, and associated challenges in the understanding of cancer development and therapeutics.
- Subjects
CANCER stem cells; HUMAN carcinogenesis; CELL populations; CANCER; DRUG resistance
- Publication
Oncolog-Hematolog, 2020, Issue 52, p43
- ISSN
2066-8716
- Publication type
Article