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- Title
Hypoxia and cervical cancer.
- Authors
Iancu, Iulia V.; Botezatu, Anca; Pleşa, Adriana; Socolov, Demetra; Huică, Irina; Fudulu, Alina; Albulescu, Adrian; Anton, Gabriela
- Abstract
Background. It has now been established that in tumors progression, aggressiveness and resistance to treatment, an important role is played by cellular hypoxia. Low oxygen levels have been detected in numerous types of malignancies, including cervical cancer, where there were associated with tumor invasion and aggressiveness. The present study aims to investigate the expression levels of hypoxia inducible factors (HIF1, HIF2A and HIF3A) in cervical carcinoma as potential biomarkers of such tumors. Method. The study group consisted of 29 specimens with squamous cell carcinoma (SCC) (21-48 years old, median: 38.5 years old). Also, as controls, there were included 20 patients with negative cytology (NILM) and negative for HPV infection. From cervical samples, total RNA was isolated using TRIzol reagent and hypoxia-related genes expression levels were estimated by qRT-PCR. Results. The data obtained show high levels for all three hypoxia genes in cervical samples compared with the control group. The best results were noticed for HIF1 (mean n-fold: 0.85; p=0.043) and HIF2A (mean n-fold: 1.825; p=0.0062). Moreover, it was observed that for SCC patients, HIF2A levels were associated significantly with tumour metastasis (p=0.025) and FIGO stage (p= 0.039). Conclusions. Our results show an important role for hypoxia inducible factors in cervical cancer and emphasize their potential to investigate tumor invasion and aggressiveness.
- Subjects
CERVICAL cancer treatment; HYPOXEMIA; CANCER invasiveness
- Publication
Oncolog-Hematolog, 2018, Issue 43, p34
- ISSN
2066-8716
- Publication type
Article