We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tumora Wilms la adultul tânăr.
- Authors
Stănculeanu, Dana Lucia; Zob, Daniela; Georgescu, Bogdan; Bunghez, Raluca Ioana
- Abstract
Nephroblastoma or Wilms' tumor is the most common renal tumor in children, only 3% of all cases are encountered in young adults. The main differential diagnoses is clear cell renal carcinoma, with similar clinical presentation, but different immunohistochemically staining. Approximately 10% of children diagnosed with Wilms'tumour have certain congenital defects (aniridia, hemi-hypertrophy or cryptorchidism). Syndromes linked to nephroblastoma include WAGR syndrome, Beckwith- Wiedemann syndrome, Deny's-Drash syndrome or trisomy 18. Adult Wilms'tumour has a poorer prognosis than pediatric Wilms tumour. Agressive treatment with multimodal approach involving surgery, chemotherapy and radiotherapy, according with pediatric NWTS guidelines showed an overall 5-year survival rate of 7085% in some clinical trials. Because of its low incidence rate, prognostic variables have not been studied on a large cohort of patients. Here, we raport a case of a 20-year-old patient with stage IV Wilms tumour, with lung and bone metastasis, with unfavourable histopathology (anaplasia) treated on a pediatric protocol, with multimodal approach.
- Subjects
NEPHROBLASTOMA; HISTOPATHOLOGY; RADIOTHERAPY; DIAGNOSIS
- Publication
Oncolog-Hematolog, 2015, Issue 31, p13
- ISSN
2066-8716
- Publication type
Article