We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations.
- Authors
Kumpei Tanisawa; Yasumichi Arai; Nobuyoshi Hirose; Hiroshi Shimokata; Yoshiji Yamada; Hisashi Kawai; Motonaga Kojima; Shuichi Obuchi; Hirohiko Hirano; Hideyo Yoshida; Hiroyuki Suzuki; Yoshinori Fujiwara; Kazushige Ihara; Maki Sugaya; Tomio Arai; Seijiro Mori; Motoji Sawabe; NorikoSato; Masaaki Muramatsu; Mitsuru Higuchi
- Abstract
Life span is a complex trait regulated by multiple genetic and environmental factors; however, the genetic determinants of extreme longevity have been largely unknown. To identify the functional coding variants associated with extreme longevity, we performed an exome-wide association study (EWAS) on a Japanese population by using an Illumina HumanExome Beadchip and a focused replication study on a Chinese population. The EWAS on two independent Japanese cohorts consisting of 530 nonagenarians/centenarians demonstrated that the G allele of CLEC3B missense variant p.S106G was associated with extreme longevity at the exome-wide level of significance (p = 2.33×10-7, odds ratio [OR] = 1.50). The CLEC3B gene encodes tetranectin, a protein implicated in the mineralization process in osteogenesis as well as in the prognosis and metastasis of cancer. The replication study consisting of 448 Chinese nonagenarians/centenarians showed that the G allele of CLEC3B p.S106G was also associated with extreme longevity (p = .027, OR = 1.51), and the p value of this variant reached 1.87×10-8 in the meta-analysis of Japanese and Chinese populations. In conclusion, the present study identified the CLEC3B p.S106G as a novel longevity-associated variant, raising the novel hypothesis that tetranectin, encoded by CLEC3B, plays a role in human longevity and aging.
- Subjects
PROTEIN genetics; GENETICS of longevity; EAST Asians; GENETICS of aging; CENTENARIANS; HEALTH; ASIANS; GENETICS; GENOMES; LONGEVITY; PROTEINS; SEQUENCE analysis
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2017, Vol 72, Issue 3, p309
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glw074