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- Title
Comparison of stress hyperglycemia ratio and glycemic gap on acute ICH in‐hospital outcomes.
- Authors
Zhang, Jia; Zhang, Qian; Gu, Hongqiu; Zhou, Qi; Li, Zixiao; Zhao, Xingquan
- Abstract
Objective: To compare the effect of different indicators on stress‐induced hyperglycemia for predicting in‐hospital outcomes of acute intracerebral hemorrhage. Methods: Using data from the Chinese Stroke Center Alliance database, which is a national, multicenter, prospective, and consecutive program. Stress‐induced hyperglycemia was described as glycemic gap (GG, defined as fasting blood glucose [FBG] minus estimated average blood glucose) and stress hyperglycemia ratio (SHR, defined as FBG‐to‐estimated average blood glucose ratio [SHR 1] or FBG‐to‐HbA1c ratio [SHR 2]). The primary outcome was in‐hospital mortality, and the second outcome was hematoma expansion. Results: A total of 71,333 patients with acute intracerebral hemorrhage were included. In multivariate analyses, the highest levels of GG (OR 1.68, 95% CI 1.12–2.51), SHR 1 (OR 1.73, 95% CI 1.15–2.60), and SHR 2 (OR 2.07, 95% CI 1.33–3.23) were associated with in‐hospital death (all the p trends <0.01). Only the highest level of SHR 2 (OR 1.24 [1.02–1.51], p trend >0.05) was related to hematoma expansion. No association between GG or SHR 1 and hematoma expansion was observed. The areas under the ROC curve of GG, SHR 1, and SHR 2 for in‐hospital mortality were 0.8808 (95% CI 0.8603–0.9014), 0.8796 (95% CI 0.8589–0.9002), and 0.8806 (95% CI 0.8600–0.9012). The areas under the ROC curve of SHR 2 for hematoma expansion were 0.7133 (95% CI 0.6964–0.7302). Interpretation: SHR (FBG‐to‐HbA1c ratio) was associated with both in‐hospital death and hematoma expansion in intracerebral hemorrhage, and might serve as an accessory indicator for the in‐hospital prognosis of intracerebral hemorrhage.
- Subjects
HYPERGLYCEMIA; CEREBRAL hemorrhage; BLOOD sugar; RECEIVER operating characteristic curves; HOSPITAL mortality
- Publication
Annals of Clinical & Translational Neurology, 2024, Vol 11, Issue 6, p1492
- ISSN
2328-9503
- Publication type
Article
- DOI
10.1002/acn3.52063