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- Title
A Walk-and-Eat Intervention Improves Outcomes for Patients With Esophageal Cancer Undergoing Neoadjuvant Chemoradiotherapy.
- Authors
Xu, Yu‐Juan; Cheng, Jason Chia‐Hsien; Lee, Jang‐Ming; Huang, Pei‐Ming; Huang, Guan‐Hua; Chen, Cheryl Chia‐Hui
- Abstract
Background. Preserving functional walking capacity and nutritional status is important for patients with esophageal cancer, but no effective intervention is available, particularly during active treatment. Methods. This pilot randomized controlled trial tested the effects of a walk-and-eat intervention for patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy. Participants with locally advanced esophageal cancer stage IIB or higher (n = 59) were randomly assigned to receive the walk-and-eat intervention (n = 30; nurse-supervised walking three times per week and weekly nutritional advice) or usual care (n = 29; control group) during 4-5 weeks of chemoradiotherapy. Primary endpoints were changes in distance on the 6-minute walk test, hand-grip strength, lean muscle mass, and body weight between initiation and completion of intervention. Results. Participants (mean age: 59.6 years) were mostly male (92.9%) with squamous cell carcinoma (96.4%). During chemoradiotherapy, participants who received the walk-and-eat intervention had 100-m less decline than controls in walk distance (adjusted p = .012), 3-kg less decrease in hand-grip strength (adjusted p = .002), and 2.7-kg less reduction in body weight (adjusted p < .001), regardless of age. The intervention group also had significantly lower rates of need for intravenous nutritional support and wheelchair use. Conclusion. The nurse-led walk-and-eat intervention is feasible and effective to preserve functional walking capacity and nutritional status for patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy.
- Subjects
TAIWAN; ANALYSIS of covariance; BIOPHYSICS; BODY weight; ONCOLOGY nursing; COMBINED modality therapy; ESOPHAGEAL tumors; GRIP strength; LONGITUDINAL method; EVALUATION of medical care; RESEARCH funding; SCIENTIFIC apparatus &; instruments; WALKING; PILOT projects; RANDOMIZED controlled trials; PRE-tests &; post-tests; CONTINUING education units; DATA analysis software; DESCRIPTIVE statistics; NUTRITIONAL status; TUMOR treatment
- Publication
Oncologist, 2015, Vol 20, Issue 10, p1216
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1634/theoncologist.2015-0178